Stroke

Blood Supply to the Brain 

The brain receives blood from the internal carotid and vertebrobasilar circulations, linked by the arterial ring called the Circle of Willis. The ACA, MCA and PCA are the major cerebral territorial arteries. The MCA arises from the internal carotid artery and is not part of the ring. The anterior and posterior circulations are connected by the posterior communicating arteries.

Diagram - The Blood Supply to the Brain

SimpleMed original by Dr. Keertana Anne

For more information on the Arterial Supply of the Brain, please see our third article in this series here. 

Territories of Cerebral Arteries 

The anterior cerebral artery (ACA), middle cerebral artery (MCA) and posterior cerebral artery (PCA) supply the three major cerebral cortical territories. They should not collectively be described as terminal branches of the Circle of Willis; the MCA arises from the internal carotid artery outside the ring.

Each of these arteries supplies a different portion of the brain, meaning that a blockage in supply of one of them will result in symptoms that can be localised to a specific region. This means that the likely location of an infarction can be worked out due to the symptoms.

Diagram - Territories supplied by the major cerebral territorial arteries on the lateral surface of the brain

Licensed under Creative Commons, Source.

Diagram - Territories supplied by the major cerebral territorial arteries on the medial surface of the brain

Licensed under Creative Commons, Source.

Symptoms of a Stroke 

Anterior Cerebral Artery

The ACA supplies the medial and superior portions of the frontal lobe and the anterior parietal lobe, including: 

• Pre-frontal cortex (executive functions - personality, decision making, planning, organisation), Supplementary motor area (changing between motor behaviours, role in speech production, micturition) 
• Paracentral lobule (primary motor and sensory cortex corresponding to contralateral lower limb (medial homunculus) and continence). 
• Corpus callosum 

Blockage to the ACA will result in the following symptoms: 

Executive Dysfunction 

Executive dysfunction is an umbrella term that describes cognitive, behavioural and emotional difficulties that occur as a symptom of another disorder, in this case a stroke. Examples of executive dysfunction in ACA infarctions are shown below: 

Apraxia

Apraxia is the inability to co-ordinate motor planning, meaning that simple motor tasks become very difficult. This presents with patients being unable to perform tasks like picking up a drink to take a sip despite knowing how to do it and having been able to do it in the past. 

Praxis depends on motor-planning networks, usually centred in the dominant hemisphere. ACA infarction involving medial frontal regions or the corpus callosum can impair purposeful movement. Callosal disconnection may cause left-hand apraxia, including after a right ACA infarct; apraxia is not restricted to dominant-hemisphere ACA lesions.

Dysarthria 

Slurred speech is also common in ACA infarcts.

Personality Changes 

Personality changes are also common in ACA infarctions due to damage to the frontal lobe. This is often noticed in the long term only, as in the acute phase the stress of the situation can mask a lot of personality changes. 

Unilateral, Contralateral Motor Weakness in the Leg / Shoulder

The ACA supplies the medial portion of the brain, which includes the regions of the motor cortex that predominantly supply the contralateral leg and trunk (according to the motor homunculus). 

The weakness will be contralateral to the side of the ischaemia as the motor impulses decussate (cross the midline) on their path from brain to muscle. 

Unilateral, Contralateral Sensory Loss in the Leg / Shoulder

The ACA supplies the medial portion of the brain, which includes the regions of the sensory cortex that predominantly supply the contralateral leg and trunk (according to the sensory homunculus). 

The sensory loss will be contralateral to the side of the ischaemia as the sensory impulses decussate (cross the midline) on their path from skin to brain.

Urinary Incontinence

The paracentral lobules are key for the control of micturition, and are made up of portions of the frontal and parietal lobes in the great longitudinal fissure (the middle bit between the two hemispheres of the brain). This midline portion of the brain is supplied by the ACA, so ischaemia in this region can lead to incontinence. 

Corpus Callosum Involvement 

The corpus callosum is supplied by the ACA, and this means that there is the potential for complex brain syndromes such as Alien Hand Syndrome and Split Brain Syndrome to occur with an infarction of the ACA. These syndromes result from the loss of the pathways through the corpus callosum, meaning the connections between the two hemispheres of the brain are significantly reduced or lost entirely. These are rare conditions. 

Middle Cerebral Artery

The MCA supplies part of the frontal lobe, and the lateral parts of the temporal and parietal lobes. 

The MCA has four main branches (lenticulostriate, superior, inferior and superficial). They all supply different portions of the MCA territory, meaning that a main trunk blockage of the MCA will take out all of them, and a small infarct may spare some regions. It is not important at this level to know which branches of the MCA supply which exact function. 

The MCA supplies: 

• Basal ganglia (motor control)
• Internal capsule (descending motor tracts)
• Lateral parts of the primary motor and sensory cortex (face,  hand and arm)
• Broca’s area in the dominant hemisphere - responsible for the production of speech
• Wernicke’s area in the dominant hemisphere - responsible for the comprehension of speech
• The optic radiations

The MCA supplies a large area of the brain, meaning that a main trunk occlusion results in the loss of a massive portion of the brain, and is therefore associated with a high mortality. 

Main trunk MCA infarctions are also prone to haemorrhagic transformation of an initially ischaemic injury, where the main trunk of the MCA is blocked and as the tissue dies, a bleed forms. 

A blockage in the MCA may result in: 

Unilateral, Contralateral Motor Weakness in the Face / Hand / Arm 

The MCA supplies the lateral portion of the brain, which includes the regions of the motor cortex that supply the face, hand, and arm (according to the motor homunculus). 

The weakness will be contralateral to the side of the ischaemia as the motor impulses decussate (cross the midline) on their path from brain to muscle. 

However, in some MCA infarctions (depending on where along the path of the MCA the infarction occurs) a full hemiparesis may be seen, including the leg and shoulder, territories supplied by the ACA not the MCA. This is due to the loss of the internal capsule, which is the common path for all motor impulses leaving the primary motor cortex. 

Unilateral, Contralateral Sensory Loss in the Face / Hand / Arm

The MCA supplies the lateral portion of the brain, which includes the regions of the sensory cortex that supply the face, hand and arm (according to the sensory homunculus). 

The sensory loss will be contralateral to the side of the ischaemia as the sensory impulses decussate (cross the midline) on their path from skin to brain.

Contralateral Homonymous Hemianopia 

Loss of the blood supply to the optic tract results in a homonymous hemianopia - this is a loss of one half of the vision on the same side of each visual field. The side of the visual field lost will be contralateral to the side of the lesion. 

The hemianopia demarcation will be exactly down the midline of the vision - this is because all impulses that are traveling down the optic tract are lost. 

For more information explaining the presentations and pathophysiology of visual lesions, please see our article here. 

Aphasia

MCA infarction can lead to three different types of aphasia depending on which areas are damaged. However, aphasia only occurs if the dominant hemisphere is damaged, as both speech and language centres are found in the dominant hemisphere. 

Broca’s Aphasia occurs when the Broca’s area of the dominant hemisphere of the brain is damaged. Broca’s area is located in the frontal lobe, and loss of function results in reduced speech fluency with preserved comprehension of the speech of others. It requires a lot of effort to produce speech, which consists of a few short words without sentence structure. Broca’s aphasia is also known as expressive aphasia. 

Wernicke’s Aphasia occurs when the Wernicke’s area of the dominant hemisphere of the brain is damaged. Wernicke’s area is located in the temporo-parietal region, and loss of function results in fluid sentences composed of muddled words. It is often described as ‘word salad’ because the patient uses many words in sentences that are unrelated to the question, and so can also be called fluent aphasia. 

Global Aphasia occurs when both Broca’s and Wernicke’s areas are damaged. This leads to the production of very few words that are not related to what the patient is trying to say. 

Hemispatial Neglect 

Hemispatial neglect occurs with a non-dominant hemisphere infarction of the MCA. It is a condition in which the patient is not able to acknowledge one entire half of their world despite the fact that they are physically able to see it. It is a loss of attention and awareness to one side of their world, and usually occurs on the contralateral side to the infarction.

It can lead to examples such as those below when the patient can follow instructions, but is only aware of one half of the task.

Diagram - Examples of Left Sided Hemispatial Neglect

Licensed under Creative Commons, Source.

Posterior Cerebral Artery

The PCA supplies the occipital visual cortex, inferior temporal regions, parts of the parietal lobe and parts of the thalamus. The optic radiations are not supplied exclusively by the PCA: their vascular supply also includes MCA and anterior choroidal branches, with variation along their course.

A blockage in the PCA may result in: 

Contralateral Homonymous Hemianopia with Macula Sparing 

Infarction of the visual cortex in PCA territory can cause contralateral homonymous hemianopia: loss of the same half of the visual field in both eyes. The pattern depends on the site and extent of the infarct.

Macular sparing means that central vision is preserved because its cortical representation near the occipital pole escapes injury. Collateral perfusion from MCA branches can contribute to this sparing after PCA occlusion. This is a cortical phenomenon, not a dual MCA/PCA blood supply to the retinal macula.

Contralateral Sensory Loss

The PCA supplies the thalamus, which is involved in the transmission of sensory impulses from the body to the cortex. A PCA infarction can therefore cause contralateral sensory loss, which is often partial rather than complete and depends on the specific thalamic nuclei affected. 

Cerebellar Infarctions

There are many different arteries that supply the cerebellum, so any cerebellar infarction may involve the superior cerebellar artery, anterior inferior cerebellar artery or posterior inferior cerebellar artery. 

An infarction in the cerebellum may result in:

Non-Specific Symptoms

Nausea, vomiting, headache, and dizziness can all be signs of cerebellar infarction, but are not enough to arouse suspicion with no other signs as they are so non-specific. 

Sudden Onset Vertigo

Any patient with risk factors for a stroke presenting with sudden onset, unrelenting and position independent vertigo should be considered for a stroke as there are few other conditions that cause truly unrelenting, sudden onset vertigo. The key is a good history to differentiate other causes of vertigo such as Meniere’s Disease or acute labyrinthitis. 

Ipsilateral Cerebellar Signs - DANISH

There are six symptoms that together represent the ‘cerebellar signs’ and suggest pathology in the cerebellum. Together they spell the mnemonic DANISH. 

Dysdiadochokinesia - the inability to perform rapidly alternative muscle movements, such as rapid pronation and supination of one hand onto the other hand, or sliding the heel of one foot up and down the front of the other shin (called the heel-shin test). 

Ataxia - a symptom characterised by a reduction in co-ordination and balance. It often results in a wide-based stance of walking, and can be confused with intoxication as the patient is unsteady and may stumble often on walking. 

Nystagmus - nystagmus is an involuntary movement of one or both eyes with a rhythmic and repetitive pattern. The rhythmic movement is made up of a slow phase (which is the pathological deviation of the eye from where it’s supposed to be) and a quick phase (which is the snap back to where it should be to maintain vision). The eye or eyes can deviate in any direction (vertical, horizontal, rotational), and so all nystagmus should be investigated for an underlying cause like a cerebellar stroke.  

Intention Tremor - an intention tremor is a tremor that is only present when trying to perform a task, and will not be present at rest. It is examined most often with the ‘finger-nose’ test, where the patient is asked to move their finger from their own nose to the examiner’s finger which is held in front of them. The tremor will be most prominent when the patient is concentrating to tap either their nose or the finger. 

Slurred Speech - slurring of the speech is a sign of a cerebellar pathology. It is important when presented with a patient with slurring of the speech to check for other cerebellar signs or signs o0f cerebral ischaemia, as slurring of the speech can also be a sign of facial muscle paralysis as seen in an MCA blockage. 

Hypotonia - reduced tone across the whole body is a sign of a cerebellar pathology. 

Brainstem Infarctions 

Contralateral Ascending and Descending Tract Loss

All sensory and motor tracts travel through the brainstem on their way between brain and spinal cord. This means that a brainstem stroke will involve the loss of the sensory and motor impulses. These signs are often contralateral because many major sensory and motor pathways cross the midline at some point between the spinal cord and brainstem. 

Ipsilateral Brainstem Signs

Brainstem signs are very complex, and you do not need to learn them in detail at this point. They share a common blood supply with the cerebellum, so some cerebellar strokes can cause brainstem signs. 

The easiest signs to explain are the paralysis of cranial nerves; cranial nerves have nuclei in the brainstem, so the loss of blood supply to this will cause a paralysis of the nerve. This will occur on the same side, as the cranial nerves and nuclei do not cross the midline. 

Basilar Artery Infarctions 

Basilar artery occlusion can cause a range of posterior-circulation syndromes, including life-threatening brainstem injury. The presentation depends on the branches involved and the extent of infarction; top-of-the-basilar and locked-in syndromes are recognised patterns rather than an exhaustive two-syndrome rule.

Distal basilar occlusion can cause top-of-the-basilar syndrome, involving rostral brainstem and posterior cerebral territories. Possible features include:

• Visual and oculomotor defects
• Altered behaviour or alertness, including dreamlike behaviour
• Hallucinations 

Injury to the ventral pons, including from basilar artery disease, can cause classic locked-in syndrome. Its features include:

• Severe paralysis of the limbs and loss of speech, with some eye movements or blinking preserved
• Preservation of consciousness 
• Preservation of vertical eye movements due to sparing of rostral midbrain structures above the level of the lesion

In classic locked-in syndrome, awareness is preserved despite severe impairment of motor output. Vertical eye movements or blinking may allow purposeful communication; the available movements depend on lesion extent.

Bamford / Oxford Classification 

The most commonly used classification system for ischaemic strokes is the Bamford or Oxford classification, and this categorises ischaemic strokes based on their initial presenting symptoms without the need for imaging. 

Total Anterior Circulation Stroke (TACS)

A TACS is a large stroke affecting a large proportion of the cortex supplied by the anterior circulation.  

It needs all three of the following symptoms: 

1. Unilateral weakness (and / or sensory deficit) of the face, arms or leg
2. Homonymous hemianopia
3. Higher cerebral dysfunction (such as dysphasia)

Partial Anterior Cerebral Stroke (PACS) 

A PACS is a less severe form of a TACS where only a portion of the area supplied by the anterior circulation is affected. 

It requires either two of the following symptoms, or isolated higher cerebral dysfunction: 

1. Unilateral weakness (and / or sensory deficit) of the face, arms or leg
2. Homonymous hemianopia
3. Higher cerebral dysfunction (such as dysphasia)

Posterior Circulation Stroke (POCS)

A POCS is a stroke involving a portion of the posterior circulation. It includes areas of the cortex supplied by the posterior cerebral arteries and infarctions of the brainstem and cerebellum. 

It needs only one of the following (classical lacunar syndromes): 

1. Cranial nerve palsy and contralateral motor or sensory deficit 
2. Bilateral motor or sensory deficit 
3. Conjugate eye movement disorder (inability to move both eyes together in the vertical or horizontal plane). 
4. Cerebellar symptoms 
5. Isolated homonymous hemianopia with macula sparing 

Lacunar Stroke (LACS)

A LACS is a subcortical stroke, a blockage in one of the small branches known as the perforating arteries. 

It needs only one of the following:

1. Pure sensory deficit 
2. Pure motor deficit 
3. Mixed sensory and motor deficit 
4. Ataxic hemiparesis (weakness and ataxia present on the same side of the body).

Edited by: Dr. Marcus Judge

Reviewed by: Adrian Judge