Leicester Medical School Phase 1 Cheat Sheet
Every unit of Leicester's Phase 1 (Years 1 and 2), semester by semester, with the SimpleMed articles that cover it. Find your unit, open the articles, revise. ESA means end-of-semester assessment, the written exam at the end of each semester.
- 4 semesters
- 21 units
- 356 SimpleMed articles
Independent guide, not endorsed by Leicester Medical School. About this page

Year 1, Semester 1
ESA 1Early Clinical Experience
10 articles
Hands-on training in the basics of patient care in a healthcare assistant role, working towards the Care Certificate (a national set of basic care standards for health and social care workers). Read up on the observations, safety and patient groups you meet on the ward.
Patient-Centred Care
From other subjects
Medical Cell Biology and Genetics (MCBG)
19 articles
The cell from the inside: organelles, proteins, enzymes and DNA, then how genes are inherited, mutated, repaired and tested for in the clinic.
Cell Physiology and Biology
- Introduction to the Cell
- Biological Membranes
- Structure of Proteins
- Enzymes and Regulation of Protein Function
- Protein Function in Oxygen Transport
- Protein Targeting
- Post-translational Modification and Collagen Biosynthesis
- Introduction to DNA
- The Cell Cycle, Checkpoints and Apoptosis
- Molecular Techniques for Medics
Genetics
- Mitosis and Meiosis
- Genotype, Phenotype, and Inheritance
- Gene Expression
- Introduction to Gene Mutation
- DNA Repair and Cancer
- Epigenetics, Genomic Imprinting and Mitochondrial Inheritance
- Genetic Testing and Counselling
From other subjects
Practice questions on SimpleMed+: Cell Physiology and Biology, Genetics
Body Logistics (Tissue Structure & Function) (Body Log)
12 articles
How cells are built into the four basic tissues (epithelium, connective tissue, muscle and nerve) and how each is specialised for its job. Histology (the study of tissues under the microscope) slides start here.
Musculoskeletal System
- Connective Tissue
- Cartilage: Structure, Growth and Repair
- Structure of Bones
- Basics of Bone Anatomy
- Joints
- Structure of the Muscles
- Anatomical Terms
From other subjects
- How to Read a Histology Slide
- Epithelium, Skin and Exocrine Glands
- Cells and Components of the Nervous System
- Post-translational Modification and Collagen Biosynthesis
- Basics of Embryology
Practice questions on SimpleMed+: Musculoskeletal System, Embryology
Metabolism, Endocrinology & Haematology (MEH)
34 articles
How the body releases, stores and regulates energy, the hormones that control it and how blood is made. Diabetes, obesity, anaemia and nutrition tie the three together.
Metabolism
- Energy Reactions in Cells
- Dietary Energy Production
- Glycolysis
- Oxygen-dependent Pathway
- Energy Storage
- Lipid Metabolism and Transport
- Protein and Amino Acid Metabolism
- Alcohol Metabolism
- Oxidative Stress
- Metabolic and Endocrine Regulation
- Temperature Regulation
- Nutrition, Diet and Body Weight
- Vitamins, Cofactors, Minerals and Trace Elements
- Purine and Pyrimidine Metabolism
- Inborn Errors of Metabolism and Newborn Screening
Endocrinology
- An Introduction to Endocrinology
- Control of Appetite
- The Endocrine Pancreas
- Diabetes Mellitus
- HPA and Growth Hormone
- Pituitary Disorders
- The Thyroid Gland
- The Adrenal Glands and Adrenal Disorders
- Calcium Metabolism
Haematology
- Haematopoiesis and the Spleen
- Iron Metabolism
- Vitamin B12 and Folate
- Full Blood Count
- Anaemia
- Haemoglobinopathies
- When Haematopoiesis Goes Wrong
- Haematology in Systemic Disease
- Blood Groups, Crossmatching and Transfusion Reactions
From other subjects
Practice questions on SimpleMed+: Metabolism, Endocrinology, Haematology
Population and Social Science
7 articles
Medicine at the scale of whole populations: how disease is measured and tracked, how studies are designed and read and how evidence and prevention shape care.
Population and Social Science
- Introduction to Population Science
- Epidemiological Studies
- Describing Data and Testing Hypotheses
- Evidence-Based Practice
- Population and Social Science Summary
From other subjects
Practice Population and Social Science questions on SimpleMed+
Year 1, Semester 2
ESA 2Infection
22 articles
How to approach a patient with a possible infection: the main bacteria, viruses, fungi and parasites, how the body fights them and how we test for and treat them.
Infection
- An Introduction to Infection
- The Infection Model
- Bacterial Structure, Classification and Growth
- Gram Staining and Infection Investigations
- Streptococci
- Staphylococci and Other Gram-positive Bacteria
- Gram-negative Bacteria: Structure, Entry Routes and Endotoxin
- The Organisms Gram Staining Misses
- Principles of Medical Virology
- Fungi and Parasites: The Eukaryotic Pathogens
- Biofilms
- Innate Immunity
- Adaptive Immunity
- The Immunocompromised Host
- Human Immunodeficiency Virus (HIV)
- Hepatitis
- Sepsis
- Travel-related Infections
- Antibiotics
From other subjects
Musculo-skeletal System (MSK)
48 articles
The bones, joints, muscles and nerves of the upper limb, lower limb and spine, learnt through the common injuries and conditions that bring patients to clinic.
Musculoskeletal System
- Anatomical Terms
- Basics of Bone Anatomy
- Structure of Bones
- Cartilage: Structure, Growth and Repair
- Connective Tissue
- Joints
- Structure of the Muscles
- Muscles in Action
- Dermatomes and Myotomes
- Bones of the Upper Limb
- Bones of the Hand
- Key Areas of the Upper Limb
- Muscles of the Shoulder
- Muscles of the Upper Arm
- Muscles of the Forearm
- The Brachial Plexus
- Conditions of the Shoulder and Clavicle
- Conditions of the Arm
- Conditions of the Elbow
- Conditions of the Wrist
- Conditions of the Hand
- Bones of the Lower Limb
- Bones of the Foot
- Key Areas of the Lower Limb
- Muscles of the Gluteal Region
- Muscles of the Thigh
- Muscles of the Lower Leg
- The Lumbar Plexus
- The Sacral Plexus
- Conditions of the Hip
- Conditions of the Thigh
- Conditions of the Knee
- Conditions of the Lower Leg
- Conditions of the Ankle
- Conditions of the Foot
- The Spine
- Conditions of the Back and Neck
- Conditions of the Lower Back
OSCE
- GALS Screening OSCE Examination
- Shoulder OSCE Examination
- Elbow OSCE Examination
- Hand and Wrist OSCE Examination
- Hip OSCE Examination
- Knee OSCE Examination
- Ankle and Foot OSCE Examination
- Spine OSCE Examination
From other subjects
Cardio-vascular System (CVS)
21 articles
How the heart and vessels are built and controlled, how we examine and image them and what goes wrong in common heart and circulation disease.
Cardiovascular System
- Anatomy of the Cardiovascular System
- Embryological Development of the CVS
- The Cardiac Cycle
- Cardiac Conduction and Contraction
- Control of Cardiac Output
- Pulses and Pressures
- Special Circulations
- Electrocardiograms
- Electrocardiogram Pathology
- Murmurs
- Hypertension
- Acute Coronary Syndrome
- Heart Failure
- Artery and Vein Disease
- Congenital Heart Defects
- Haemodynamic Shock
- Cardiovascular Drugs
OSCE
- Cardiovascular System OSCE Examination
- Peripheral Vascular OSCE Examination
- Blood Pressure Measurement OSCE Guide
From other subjects
Introduction to Physiology and Pharmacology
13 articles
How cells move ions, fire signals and talk to each other, and how drugs exploit those same receptors and pathways. Pharmacokinetics (what the body does to a drug) and pharmacodynamics (what a drug does to the body) begin here.
Cell Physiology and Biology
- Biological Membranes
- Membrane Transport and Intracellular Calcium Regulation
- Membrane Potentials
- Action Potentials
- G-Protein Coupled Receptors
- Enzyme-linked and Intracellular Receptor Signalling
- Autonomic Nervous System Introduction
Pharmacology
- Pharmacokinetics
- Pharmacodynamics
- Cholinergic Pharmacology
- Adrenergic Pharmacology
- Research Methods in Pharmacology
From other subjects
Practice questions on SimpleMed+: Cell Physiology and Biology, Pharmacology
Pathological Processes
17 articles
The handful of processes behind most disease: inflammation, repair, adaptation, thrombosis and cancer.
Pathology
- Basics of Pathology
- An Introduction to Pathology
- How to Read a Histology Slide
- Cellular Adaptations
- Acute Inflammation
- Chronic Inflammation
- Regeneration and Repair of Tissues
- The Lymphatic System
- Haemostasis and Clotting
- Thrombosis and Embolism
- Atherosclerosis
- Introduction to Neoplasia
- Pathogenesis of Neoplasms
- Behaviour of Neoplasms
- Epithelium, Skin and Exocrine Glands
From other subjects
Population and Social Science 2
8 articles
The patient behind the disease: how beliefs, behaviour and social circumstances affect health, how care is kept safe and how health promotion changes behaviour.
Population and Social Science
- Models of Health
- Beliefs of the Public
- Health Economics
- Patient Safety and Quality Control
- Population and Social Science Summary
Patient-Centred Care
Practice questions on SimpleMed+: Population and Social Science, Patient-Centred Care
Year 2, Semester 3
ESA 3Gastrointestinal System
21 articles
The gut from mouth to rectum, plus the liver, gallbladder and pancreas: how they develop, digest and absorb, and the common diseases that disrupt them.
Gastrointestinal System
- Development of the Gastrointestinal Tract
- Anatomy and Physiology of the Foregut
- Anatomy and Physiology of the Midgut
- Anatomy and Physiology of the Hindgut
- Abdominal Wall and Inguinal Canal
- Gastrointestinal Motility and the Enteric Nervous System
- Gastrointestinal Secretion, Digestion and Absorption
- Liver, Biliary and Exocrine Pancreatic Physiology
- Upper Gastrointestinal Tract Pathology
- Intestinal Pathology
- Distal Gastrointestinal Tract Pathology
- Hepatic, Biliary and Pancreatic Pathology
- Gastroenteritis and Enterocolitis
- Gastrointestinal Malignancy
- Gastrointestinal Emergencies
OSCE
From other subjects
Reproductive System
25 articles
Male and female reproductive anatomy, the menstrual cycle, pregnancy, birth and the menopause, along with common gynaecological, obstetric and breast conditions.
Reproductive System
- Anatomy of the Woman
- Anatomy of the Man
- The Pelvic Floor
- Development of the Reproductive System
- Gametogenesis
- Puberty
- The Menstrual Cycle and Menstrual Abnormalities
- Sex, Infertility and Contraception
- The Placenta
- Physiology of the Mother
- Physiology of the Fetus
- Diseases of the Mother in Pregnancy
- Labour and Delivery
- The Postpartum Period
- The Menopause
- Infections of the Reproductive Tract
- Pelvic Inflammatory Disease
- Malignancies of the Reproductive Tract
- Introduction to the Breast
- Benign Conditions of the Breast
- Malignant Breast Disease
From other subjects
Urinary System
21 articles
How the kidneys filter blood and control water, salt, potassium and acid, how kidney function is measured and the diseases of the kidneys, bladder and prostate.
Urinary System
- Anatomy of the Kidneys, Bladder and Urethra
- Development of the Urinary System
- The Nephron
- Glomerular Filtration Rate and the Measurement of Kidney Function
- The Glomerulus: Tubular Reabsorption and Secretion
- Control of Plasma Osmolarity
- Control of Plasma Volume
- Control of Potassium
- Hyponatraemia
- Micturition
- Diuretics
- Acute Kidney Injury
- Chronic Kidney Disease
- Glomerular Disease
- Diabetic Nephropathy
- Urinary Tract Infections
- Urinary Tract Obstruction
- Urinary Incontinence
- Male Urological Conditions
- Prostate Pathology
- Urological Malignancy
Respiratory System
17 articles
How we breathe, exchange gases and keep blood pH steady, how lung function is tested and the common airway, infective and malignant lung diseases.
Respiratory System
- Anatomy of the Respiratory System
- Development of the Respiratory System
- Ventilation and Lung Mechanics
- Properties of Gas Exchange
- Carbon Dioxide Transport
- Chemical Control of Breathing and Plasma pH
- Lung Function Testing
- Asthma
- Chronic Obstructive Pulmonary Disease
- Pneumonia and other Lower Respiratory Tract Infections
- Tuberculosis
- Bronchiectasis and Cystic Fibrosis
- Pneumothorax and Pleural Effusion
- Pulmonary Embolism
- Lung Cancer
- Respiratory Failure
From other subjects
Applied Head and Neck Anatomy and Introduction to Neuroanatomy (H&N)
29 articles
The skull, face, neck and special senses in their clinical context, the cranial nerves and a first look at the brain, its coverings and its blood supply.
Head and Neck
- Introduction to Head & Neck Anatomy
- Development of the Head and Neck
- The Skull
- Fascial Planes, Muscles and Triangles
- Blood Supply to the Head and Neck
- Autonomics of the Head and Neck
- Cranial Nerves I-VI
- Cranial Nerves VII-XII
- The Temporomandibular Joint (TMJ)
- The Oral Cavity and Pharynx
- The Nose
- The Larynx
- The Eye
- Anatomy of the Ear
- Ear Pathology
- Lymph Nodes and Neck Lumps
- Head and Neck Cancers
- Imaging of the Head and Neck
- The Meninges
Neuroanatomy and Psychiatry
- Basics of Neuroanatomy
- Development of the Nervous System
- Arterial Supply to the Brain
- Production and Circulation of CSF and Related Disorders
OSCE
- Cranial Nerve OSCE Examination
- Eye and Vision OSCE Examination
- Ear, Otoscopy and Hearing OSCE Examination
- Nasal OSCE Examination
- Neck Lump OSCE Examination
- Thyroid Status OSCE Examination
Practice questions on SimpleMed+: Head and Neck, Neuroanatomy and Psychiatry
Year 2, Semester 4
ESA 4Clinical Immunology
14 articles
How the immune system protects us, and what happens when it overreacts, attacks the body or fails, taught through allergy, autoimmunity and immunodeficiency.
Infection
Immunology
- Hypersensitivity Reactions
- Type 1 Hypersensitivity
- Food Allergy
- Introduction to Autoimmunity
- Systemic Lupus Erythematosus
- Rheumatoid Arthritis
- Immunological Therapies
From other subjects
Clinical Pharmacology Therapeutics & Principles of Prescribing
29 articles
Pharmacology applied to real patients, system by system and drug class by drug class, plus the principles of writing a safe prescription.
Pharmacology
- Safe Prescribing
- Pharmacokinetics
- Pharmacodynamics
- Pharmacovigilance and Pharmacogenetics
- Poisoning and STOPP/START
- Research Methods in Pharmacology
- Hypertension and Heart Failure
- Cardiac Arrhythmias
- Antiplatelets, Anticoagulants and Thrombolysis
- Hyperlipidaemias
- Diuretics and Renal Pharmacology
- Pharmacology of Airway Control
- Drugs Affecting Acid Secretion
- Antiemetics and Laxatives
- Pharmacology of Insulin
- Reproductive and Post-reproductive Health
- Antibiotics
- Antivirals
- Cancer Chemotherapy
- Immunosuppression and Disease-modifying Therapy
- NSAIDs
- Opioids
- Anaesthetics
- Epilepsy and Anti-epileptic Drugs
- Parkinson's Disease and Myasthenia Gravis
- Introduction to Psychopharmacology
- Cholinergic Pharmacology
- Adrenergic Pharmacology
From other subjects
Integration for Clinical Application
14 articles
Revisits Phase 1 from new angles, with a focus on older people, children and other patient groups with particular needs.
Patient-Centred Care
From other subjects
Clinical Neuroscience
30 articles
How the brain and nerves work and the neuroscience behind common neurological, psychological and psychiatric conditions, from stroke and dementia to mood disorders and psychosis.
Neuroanatomy and Psychiatry
- Basics of Neuroanatomy
- Cells and Components of the Nervous System
- Development of the Nervous System
- Arterial Supply to the Brain
- Production and Circulation of CSF and Related Disorders
- Somatosensory System
- Motor System
- The Cerebellum: Circuits, Coordination and Clinical Signs
- Reticular Formation
- The Hypothalamus and Limbic System
- Higher Cortical Function
- Visual System
- Auditory and Vestibular Systems
- Stroke
- Subarachnoid Haemorrhage
- Raised Intracranial Pressure
- Headaches
- Movement Disorders
- Infections of the Central Nervous System
- Dementia
- Delirium
- Mood Disorders
- Anxiety and Anxiety Disorders
- Psychosis
Pharmacology
- Epilepsy and Anti-epileptic Drugs
- Parkinson's Disease and Myasthenia Gravis
- Introduction to Psychopharmacology
OSCE
- Upper Limb Neurological OSCE Examination
- Lower Limb Neurological OSCE Examination
- Cerebellar OSCE Examination
Practice Neuroanatomy and Psychiatry questions on SimpleMed+
Throughout Years 1 and 2
Compassionate Holistic Diagnostic Detective Course (CHDD) Semesters 1 to 4
50 articles
Runs alongside every semester. You learn to take a history, examine each body system and communicate well with patients, relatives and colleagues, first with actors and then with real patients.
Browse every examination guide on the SimpleMed OSCE hub
Start here
- Index Conditions for OSCE exams
- Blood Pressure Measurement OSCE Guide
- Venepuncture and Blood Cultures OSCE Guide
Heart, lungs and circulation
- Cardiovascular System OSCE Examination
- Respiratory System OSCE Examination
- Peripheral Vascular OSCE Examination
- Varicose Vein OSCE Examination
- Deep Vein Thrombosis (DVT) OSCE Examination
Abdomen and groin
- Abdominal OSCE Examination
- Rectal (PR) OSCE Examination
- Stoma OSCE Examination
- Hernia OSCE Examination
- Testicular OSCE Examination
Nervous system
- Cranial Nerve OSCE Examination
- Upper Limb Neurological OSCE Examination
- Lower Limb Neurological OSCE Examination
- Cerebellar OSCE Examination
Joints and spine
- GALS Screening OSCE Examination
- Shoulder OSCE Examination
- Elbow OSCE Examination
- Hand and Wrist OSCE Examination
- Hip OSCE Examination
- Knee OSCE Examination
- Ankle and Foot OSCE Examination
- Spine OSCE Examination
Endocrine
- Thyroid Status OSCE Examination
- Diabetic Foot OSCE Examination
- Cushing's Syndrome OSCE Examination
- Acromegaly OSCE Examination
Eyes, ears, nose and neck
- Eye and Vision OSCE Examination
- Visual Acuity OSCE Assessment
- Fundoscopy (Ophthalmoscopy) OSCE Examination
- Anterior Segment Eye OSCE Examination
- Ear, Otoscopy and Hearing OSCE Examination
- Nasal OSCE Examination
- Neck Lump OSCE Examination
Skin, breast and lymph nodes
- Pigmented Skin Lesion OSCE Examination
- Rash and Non-Pigmented Skin Lesion OSCE Examination
- Breast OSCE Examination
- Lymphoreticular OSCE Examination
Surface anatomy
The wider consultation
Practice questions on SimpleMed+: OSCE, Patient-Centred Care
How Leicester assesses Phase 1
- Each of the four semesters ends with an end-of-semester assessment, known to students as ESA 1 to ESA 4. Units are grouped by semester, so each semester section is one ESA.
- Phase 1 ends with a formal clinical exam, so the consultation and examination skills from the Compassionate Holistic Diagnostic Detective Course matter from Semester 1.
- Leicester Medical School publishes the official dates and formats. Always check your own course materials.
Test yourself
Reading is half of revision. Each unit above links to matching single best answer questions on SimpleMed+.
SimpleMed+ Encyclopaedia
Hard topics, made short and simple
A free bank of short and simple explanations of complex topics, with memory aids, in bitesize pages. Each one links to the SimpleMed+ questions that test it and to the core knowledge your exams expect.
- Bitesize explanations
- Memory aids
- Linked to the question bank
Getting ready for clinical
Phase 2 (Years 3 to 5) is the clinical phase, spent on placements in hospitals, general practice and the community.
This is an independent revision guide written by SimpleMed. It is not endorsed by, or affiliated with, Leicester Medical School or the University of Leicester. Unit names follow Leicester's published Phase 1 curriculum, and the article mapping is our own; always check your official course materials. Last updated October 2026.

